Analysis Note

Colour (visual): white to yellow to beigeAppearance of substance (visual): beadsLoading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.50 - 0.80 mmol/gSwelling Volume (in DMF): lot specific result

General description

Fmoc-PAL-AM resin consists of Barany′s aminomethyl-dimethoxyphenoxyvaleric acid linker [1] attached to aminomethylated polystyrene. The amino group of this linker can be easily acylated under standard coupling conditions. Following peptide assembly, treatment with 95% TFA containing scavengers releases the desired peptide amide. Studies have shown the acid sensitivity of this linker to be around twice that of the Rink amide linker [2]. There is some evidence to suggest that PAL resins give greater yields in microwave assisted synthesis.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany